Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway

Fatty acid synthase (FASN), the main enzyme involved in de novo lipogenesis, is overexpressed in several types of tumor tissues. In addition, it is associated with tumor cell proliferation, metastasis, epithelial-mesenchymal transition (EMT) and a poor prognosis. However, the precise functions and i...

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Publicado no:Oncol Lett
Main Authors: Sun, Liang, Yao, Yizhou, Pan, Guofeng, Zhan, Shenghua, Shi, Weiqiang, Lu, Ting, Yuan, Jinfeng, Tian, Kangjun, Jiang, Linhua, Song, Shiduo, Zhu, Xinguo, He, Songbing
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006441/
https://ncbi.nlm.nih.gov/pubmed/29928446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2018.8648
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