Large libraries reveal diverse solutions to an RNA recognition problem

RNA loops that adopt a characteristic GNRA “tetraloop” fold are common in natural RNAs. Here, we have used in vitro selection by means of mRNA-peptide fusions to select peptides that bind an example of this RNA loop motif. Starting with the RNA recognition domain from the λ N protein, we have constr...

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Bibliographic Details
Main Authors: Barrick, Jeffrey E., Takahashi, Terry T., Ren, Jinsong, Xia, Tianbing, Roberts, Richard W.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC60061/
https://ncbi.nlm.nih.gov/pubmed/11675487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221467798
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