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How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration
Aryl-hydrocarbon receptor interacting protein-like 1 (AIPL1) is essential to stabilize cGMP phosphodiesterase 6 (PDE6) in rod photoreceptors. Mutation of AIPL1 leads to loss of PDE6, accumulation of intracellular cGMP, and rapid degeneration of rods. To understand the metabolic basis for the photore...
Kaydedildi:
| Yayımlandı: | Adv Exp Med Biol |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6005689/ https://ncbi.nlm.nih.gov/pubmed/29721955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-319-75402-4_35 |
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