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CRR9/CLPTM1L Regulates Cell Survival Signaling and is Required for Ras Transformation and Lung Tumorigenesis
The transmembrane protein CLPTM1L is overexpressed in non-small cell lung cancer (NSCLC) where it protects tumor cells from genotoxic apoptosis. Here we show that RNAi-mediated blockade of CLPTM1L inhibits K-Ras-induced lung tumorigenesis. CLPTM1L expression was required in vitro for morphological t...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6005686/ https://ncbi.nlm.nih.gov/pubmed/24366883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1617 |
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