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Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner
Mutations in mitochondrial DNA are an important source of severe and incurable human diseases. The vast majority of these mutations are heteroplasmic, meaning that mutant and wild-type genomes are present simultaneously in the same cell. Only a very high proportion of mutant mitochondrial DNA (heter...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | PLoS One |
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Κύριοι συγγραφείς: | , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Public Library of Science
2018
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6005506/ https://ncbi.nlm.nih.gov/pubmed/29912984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199258 |
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