Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

How fully differentiated cells that experience carcinogenic insults become proliferative cancer progenitors that acquire multiple initiating mutations is not clear. This question is of particular relevance to hepatocellular carcinoma (HCC), which arises from differentiated hepatocytes. Here we show...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Dhar, Debanjan, Antonucci, Laura, Nakagawa, Hayato, Kim, Ju Youn, Glitzner, Elisabeth, Caruso, Stefano, Shalapour, Shabnam, Yang, Ling, Valasek, Mark A, Lee, Sooyeon, Minnich, Kerstin, Seki, Ekihiro, Tuckermann, Jan, Sibilia, Maria, Zucman-Rossi, Jessica, Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005359/
https://ncbi.nlm.nih.gov/pubmed/29894692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.003
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