Icariside II ameliorates endothelial dysfunction by regulating the MAPK pathway via miR-126/SPRED1 in diabetic human cavernous endothelial cells

AIM: The aim of the study was to investigate whether miR-126, a regulator of MAPK signaling via targeting sprouty-related EVH1 domain-containing protein 1 (SPRED1) mRNA, is involved in the process by which icariside II (ICA II) ameliorates endothelial dysfunction in human cavernous endothelial cells...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Lei, Hongen, Li, Huixi, Tian, Long, Li, Meng, Xin, Zhongcheng, Zhang, Xiaodong, Guan, Ruili
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005314/
https://ncbi.nlm.nih.gov/pubmed/29942117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S166734
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