Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(−/−)) murine hearts

INTRODUCTION: Ageing and age-related bioenergetic conditions including obesity, diabetes mellitus and heart failure constitute clinical ventricular arrhythmic risk factors. MATERIALS AND METHODS: Pro-arrhythmic properties in electrocardiographic and intracellular recordings were compared in young an...

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Publicat a:Mech Ageing Dev
Autors principals: Ahmad, Shiraz, Valli, Haseeb, Chadda, Karan R., Cranley, James, Jeevaratnam, Kamalan, Huang, Christopher L.-H.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science Ireland 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004599/
https://ncbi.nlm.nih.gov/pubmed/29763629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2018.05.004
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