Galectin-8 induces partial epithelial–mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin–Darby canine kidney cells

Epithelial cells can acquire invasive and tumorigenic capabilities through epithelial–mesenchymal-transition (EMT). The glycan-binding protein galectin-8 (Gal-8) activates selective β1-integrins involved in EMT and is overexpressed by certain carcinomas. Here we show that Gal-8 overexpression or exo...

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Udgivet i:Mol Biol Cell
Main Authors: Oyanadel, Claudia, Holmes, Christopher, Pardo, Evelyn, Retamal, Claudio, Shaughnessy, Ronan, Smith, Patricio, Cortés, Priscilla, Bravo-Zehnder, Marcela, Metz, Claudia, Feuerhake, Teo, Romero, Diego, Roa, Juan Carlos, Montecinos, Viviana, Soza, Andrea, González, Alfonso
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004583/
https://ncbi.nlm.nih.gov/pubmed/29298841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-05-0301
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