Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

C1q, a member of the immune complement cascade, is implicated in the selective pruning of synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown to occur during brain development, while increased activation and complement-dependent synapse loss is observed in neurodegen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Györffy, Balázs A., Kun, Judit, Török, György, Bulyáki, Éva, Borhegyi, Zsolt, Gulyássy, Péter, Kis, Viktor, Szocsics, Péter, Micsonai, András, Matkó, János, Drahos, László, Juhász, Gábor, Kékesi, Katalin A., Kardos, József
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004452/
https://ncbi.nlm.nih.gov/pubmed/29844190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722613115
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