Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

Limited efficacy of current antivirals and antiviral-resistant mutations impairs anti-influenza treatment. Here, we evaluate the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Viral replication is significantly reduced in cell lines transfected...

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Udgivet i:Nat Commun
Main Authors: Zhao, Hanjun, To, Kelvin K. W., Chu, Hin, Ding, Qiulu, Zhao, Xiaoyu, Li, Cun, Shuai, Huiping, Yuan, Shuofeng, Zhou, Jie, Kok, Kin-Hang, Jiang, Shibo, Yuen, Kwok-Yung
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004018/
https://ncbi.nlm.nih.gov/pubmed/29907765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04792-7
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