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Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA
Cohesin is a fundamental protein complex that holds sister chromatids together. Separase protease cleaves a cohesin subunit Rad21/SCC1, causing the release of cohesin from DNA to allow chromosome segregation. To understand the functional organization of cohesin, we employed next-generation whole-gen...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003501/ https://ncbi.nlm.nih.gov/pubmed/29735656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803564115 |
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