Lymph node metastases can invade local blood vessels, exit the node and colonize distant organs in mice

Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognosis and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mam...

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Pubblicato in:Science
Autori principali: Pereira, Ethel R., Kedrin, Dmitriy, Seano, Giorgio, Gautier, Olivia, Meijer, Eelco F.J., Jones, Dennis, Chin, Shan-Min, Kitahara, Shuji, Bouta, Echoe M., Chang, Jonathan, Beech, Elizabeth, Jeong, Han-Sin, Carroll, Michael C., Taghian, Alphonse G., Padera, Timothy P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002772/
https://ncbi.nlm.nih.gov/pubmed/29567713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal3622
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