Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound

Influenza virus (IV) infections cause severe respiratory illnesses that can be complicated by bacterial super-infections. Previously, we identified the cellular Raf-MEK-ERK cascade as a promising antiviral target. Inhibitors of MEK, such as CI-1040, showed potent antiviral activity. However, it rema...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bruchhagen, Christin, Jarick, Marcel, Mewis, Carolin, Hertlein, Tobias, Niemann, Silke, Ohlsen, Knut, Peters, Georg, Planz, Oliver, Ludwig, Stephan, Ehrhardt, Christina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002397/
https://ncbi.nlm.nih.gov/pubmed/29904167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27445-7
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