Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease

AIMS: Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high-density lipoprotein (HDL) that promotes hepatic uptake of cholesterol from HDL. A rare mutation p.P376L, in the gene encoding SR-BI, SCARB1, was recently reported to associate with elevated HDL cholesterol (HDL-C) and incre...

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Foilsithe in:Eur Heart J
Main Authors: Helgadottir, Anna, Sulem, Patrick, Thorgeirsson, Gudmundur, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Jensson, Brynjar Ö, Arnadottir, Gudny A, Olafsson, Isleifur, Eyjolfsson, Gudmundur I, Sigurdardottir, Olof, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, Stefansson, Kari
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2018
Ábhair:
Basic Science
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001888/
https://ncbi.nlm.nih.gov/pubmed/29596577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehy169
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