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Aging‐associated changes in hippocampal glycogen metabolism in mice. Evidence for and against astrocyte‐to‐neuron lactate shuttle

Lactate derived from astrocytic glycogen has been shown to support memory formation in hippocampi of young animals, inhibiting it in old animals. Here we show, using quantitative mass spectrometry‐based proteomics, immunofluorescence, and qPCR that aging is associated with an increase of glycogen me...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Drulis‐Fajdasz, Dominika, Gizak, Agnieszka, Wójtowicz, Tomasz, Wiśniewski, Jacek R., Rakus, Dariusz
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001795/
https://ncbi.nlm.nih.gov/pubmed/29493012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23319
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