Nucleic acid polymer REP 2139 and nucleos(T)ide analogues act synergistically against chronic hepadnaviral infection in vivo in Pekin ducks

Nucleic acid polymer (NAP) REP 2139 treatment was shown to block the release of viral surface antigen in duck HBV (DHBV)‐infected ducks and in patients with chronic HBV or HBV/hepatitis D virus infection. In this preclinical study, a combination therapy consisting of REP 2139 with tenofovir disoprox...

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Publicat a:Hepatology
Autors principals: Quinet, Jonathan, Jamard, Catherine, Burtin, Madeleine, Lemasson, Matthieu, Guerret, Sylviane, Sureau, Camille, Vaillant, Andrew, Cova, Lucyna
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001552/
https://ncbi.nlm.nih.gov/pubmed/29251788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29737
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