Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium

Aging increases the risk of abrupt declines in cognitive function after an event that triggers immune system activation (e.g. surgery, infection, or injury). This phenomenon is poorly understood, but rodent models may provide clues. We have previously shown that aging (24-mo-old) F344xBN rats genera...

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Publicat a:eNeuro
Autors principals: Tanaka, Naoto, Cortese, Giuseppe P., Barrientos, Ruth M., Maier, Steven F., Patterson, Susan L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2018
Matèries:
New Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001264/
https://ncbi.nlm.nih.gov/pubmed/29911174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0009-18.2018
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