PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer

BACKGROUND AND OBJECTIVE: Maintenance of genomic integrity is essential to ensure normal organismal development and to prevent diseases such as cancer. PR-Set7 (also known as Set8) is a cell cycle regulated enzyme that catalyses monomethylation of histone 4 at Lys20 (H4K20me1) to promote chromosome...

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Publicat a:Zhongguo Fei Ai Za Zhi
Autors principals: WANG, Yang, XU, Zhidong, MAO, Jian-Hua, HSIEH, David., AU, Alfred, JABLONS, David M., LI, Hui, YOU, Liang
Format: Artigo
Idioma:Inglês
Publicat: 中国肺癌杂志编辑部 2015
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999902/
https://ncbi.nlm.nih.gov/pubmed/26104890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3779/j.issn.1009-3419.2015.06.15
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