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Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines

Here we report highly efficient and chemoselective azadiene–imine reductive couplings catalyzed by (Ph-BPE)Cu–H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereomer of product in >95:5 er. The products’ d...

詳細記述

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書誌詳細
出版年:J Am Chem Soc
主要な著者: Shao, Xinxin, Li, Kangnan, Malcolmson, Steven J.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999589/
https://ncbi.nlm.nih.gov/pubmed/29775301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04750
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