NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor

NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2 FnIII2 domains both contain a Walker A motif. In NCAM1 binding of ATP to this moti...

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Pubblicato in:Sci Rep
Autori principali: Rasmussen, Kim Krighaar, Falkesgaard, Maria Hansen, Winther, Malene, Roed, Nikolaj Kulahin, Quistgaard, Christine Louise, Teisen, Marie Nygaard, Edslev, Sofie Marie, Petersen, David Leander, Aljubouri, Ali, Christensen, Claus, Thulstrup, Peter Waaben, Lo Leggio, Leila, Teilum, Kaare, Walmod, Peter Schledermann
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997747/
https://ncbi.nlm.nih.gov/pubmed/29895898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27089-7
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