Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity

The benzodiazepine benzomalvin A/D is a fungally derived specialized metabolite and inhibitor of the substance P receptor NK1, biosynthesized by a three-gene nonribosomal peptide synthetase cluster. Here, we utilize fungal artificial chromosomes with metabolomic scoring (FAC-MS) to perform molecular...

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Publicado en:Biochemistry
Main Authors: Clevenger, Kenneth D., Ye, Rosa, Bok, Jin Woo, Thomas, Paul M., Islam, Md Nurul, Miley, Galen P., Robey, Matthew T., Chen, Cynthia, Yang, KaHoua, Swyers, Michael, Wu, Edward, Gao, Peng, Wu, Chengcang C., Keller, Nancy P., Kelleher, Neil L.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997561/
https://ncbi.nlm.nih.gov/pubmed/29533658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00076
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