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Multivalent Presentation of Peptide Targeting Groups Alters Polymer Biodistribution to Target Tissues

Drug delivery to bone is challenging, whereby drug distribution is commonly <1% of injected dose, despite development of several bone-targeted drug delivery systems specific to hydroxyapatite. These bone-targeted drug delivery systems still suffer from poor target cell localization within bone, a...

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Detalhes bibliográficos
Publicado no:Biomacromolecules
Main Authors: Newman, Maureen R., Russell, Steven G., Schmitt, Christopher S., Marozas, Ian A., Sheu, Tzong-Jen, Puzas, J. Edward, Benoit, Danielle S. W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997262/
https://ncbi.nlm.nih.gov/pubmed/29227674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.7b01193
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