Negative regulation of cationic nanoparticle-induced inflammatory toxicity through the increased production of prostaglandin E2 via mitochondrial DNA-activated Ly6C(+) monocytes

Rationale: Cationic nanocarriers present with well-known toxicities, including inflammatory toxicity, which limit their clinical application. How the cationic nanocarrier-induced inflammatory response is negatively regulated is unknown. Herein, we found that following a sublethal dose of cationic na...

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Publicado en:Theranostics
Autores principales: Liu, Li, Liu, Yantong, Xu, Bocheng, Liu, Chuyu, Jia, Yanpeng, Liu, Ting, Fang, Chunju, Wang, Wei, Ren, Jun, He, Zhiyao, Men, Ke, Liang, Xiao, Luo, Min, Shao, Bin, Mao, Ye, Xiao, Henyi, Qian, Zhiyong, Geng, Jia, Dong, Birong, Mi, Peng, Jiang, Yu, Wei, Yuquan, Wei, Xiawei
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996362/
https://ncbi.nlm.nih.gov/pubmed/29896308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.21693
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