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Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects

Rationale: Atherosclerosis is a chronic inflammatory and epigenetic disease that is influenced by different patterns of blood flow. However, the epigenetic mechanism whereby atheroprotective flow controls endothelial gene programming remains elusive. Here, we investigated the possibility that flow a...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Xu, Suowen, Xu, Yanni, Yin, Meimei, Zhang, Shuya, Liu, Peng, Koroleva, Marina, Si, Shuyi, Little, Peter J., Pelisek, Jaroslav, Jin, Zheng Gen
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996356/
https://ncbi.nlm.nih.gov/pubmed/29896299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.21966
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