Efficacy and safety of trastuzumab, lapatinib, and paclitaxel neoadjuvant treatment with or without prolonged exposure to anti-HER2 therapy, and with or without hormone therapy for HER2-positive primary breast cancer: a randomised, five-arm, multicentre, open-label phase II trial

BACKGROUND: Dual blockade of HER2 promises increased pathological complete response (pCR) rate compared with single blockade in the presence of chemotherapy for HER2-positive (+) primary breast cancer. Many questions remain regarding optimal duration of treatment and combination impact of endocrine...

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Detalhes bibliográficos
Publicado no:Breast Cancer
Main Authors: Masuda, N., Toi, M., Yamamoto, N., Iwata, H., Kuroi, K., Bando, H., Ohtani, S., Takano, T., Inoue, K., Yanagita, Y., Kasai, H., Morita, S., Sakurai, T., Ohno, S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996004/
https://ncbi.nlm.nih.gov/pubmed/29445928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12282-018-0839-7
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