Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine

Dnmt2 methylates cytosine at position 38 of tRNA(Asp) in a variety of eukaryotic organisms. A correlation between the presence of the hypermodified nucleoside queuosine (Q) at position 34 of tRNA(Asp) and the Dnmt2 dependent C38 methylation was recently found in vivo for S. pombe and D. discoideum....

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Udgivet i:Sci Rep
Main Authors: Johannsson, Sven, Neumann, Piotr, Wulf, Alexander, Welp, Luisa M., Gerber, Hans-Dieter, Krull, Matthias, Diederichsen, Ulf, Urlaub, Henning, Ficner, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995894/
https://ncbi.nlm.nih.gov/pubmed/29892076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27118-5
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