MeDIP combined with in-solution targeted enrichment followed by NGS: Inter-individual methylation variability of fetal-specific biomarkers and their implementation in a proof of concept study for NIPT

DNA methylation is the most characterized epigenetic process exhibiting stochastic variation across different tissues and individuals. In non-invasive prenatal testing (NIPT) fetal specific methylated regions can potentially be used as biomarkers for the accurate detection of fetal aneuploidies. The...

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Pubblicato in:PLoS One
Autori principali: Keravnou, Anna, Ioannides, Marios, Loizides, Charalambos, Tsangaras, Kyriakos, Achilleos, Achilleas, Mina, Petros, Kypri, Elena, Hadjidaniel, Michael D., Neofytou, Maria, Kyriacou, Skevi, Sismani, Carolina, Koumbaris, George, Patsalis, Philippos C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995407/
https://ncbi.nlm.nih.gov/pubmed/29889893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199010
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