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Mass spectrometric detection of iron nitrosyls, sulfide oxidation and mycothiolation during nitrosylation of the NO sensor [4Fe–4S] NsrR

The bacterial nitric oxide (NO)-sensing transcriptional regulator NsrR binds a [4Fe–4S] cluster that enables DNA-binding and thus repression of the cell's NO stress response. Upon exposure to NO, the cluster undergoes a complex nitrosylation reaction resulting in a mixture of iron-nitrosyl spec...

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Pubblicato in:Chem Commun (Camb)
Autori principali: Crack, Jason C., Hamilton, Chris J., Le Brun, Nick E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994877/
https://ncbi.nlm.nih.gov/pubmed/29790499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc01339j
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