Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis

BACKGROUND: Inflammasomes, which mediate maturation of interleukin-1β (IL-β) and interleukin-18 (IL-18) and lead to pyroptosis, have been linked to various autoimmune disorders. This study investigated whether they are involved in the pathogenesis of autoimmune thyroiditis (AIT). METHODS: We collect...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Guo, Qingling, Wu, Ying, Hou, Yuanyuan, Liu, Yongping, Liu, Tingting, Zhang, Hao, Fan, Chenling, Guan, Haixia, Li, Yushu, Shan, Zhongyan, Teng, Weiping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994487/
https://ncbi.nlm.nih.gov/pubmed/29915579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01197
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