SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn's Disease with Significant Inverse Correlation to Disease Activity

BACKGROUND: Small mothers against decapentaplegic (SMAD)4 and SMAD7 are key regulatory components in the immunosuppressive transforming growth factor- (TGF-) β signaling pathway, which is defective in inflammatory bowel disease (IBD). SMAD4 may play an important role in the pathogenesis of IBD as in...

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Detalhes bibliográficos
Publicado no:Gastroenterol Res Pract
Main Authors: Klausen, Pia, Karstensen, John Gásdal, Coskun, Mehmet, Săftoiu, Adrian, Vilmann, Peter, Cowland, Jack Bernard, Riis, Lene Buhl
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994270/
https://ncbi.nlm.nih.gov/pubmed/29977289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9307848
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