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Calpain inhibition attenuates bleomycin-induced pulmonary fibrosis via switching the development of epithelial-mesenchymal transition

Calpains are intracellular calcium-dependent cysteine proteases, which cleave several substrates proteins, have been proven to play important roles in lung fibrosis. The aim of this study was to investigate the effects of calpain on bleomycin (BLM)-induced pulmonary fibrosis. A lung fibrosis mice mo...

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Detalhes bibliográficos
Publicado no:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Liu, Yuan, Liu, Bing, Zhang, Gu-qin, Zou, Jing-feng, Zou, Meng-lin, Cheng, Zhen-shun
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994212/
https://ncbi.nlm.nih.gov/pubmed/29666896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-018-1499-z
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