SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation

Regulation of transcription is fundamental to the control of cellular gene expression and function. Although recent studies have revealed a role for the oncoprotein MYC in amplifying global transcription, little is known as to how the global transcription is suppressed. Here we report that SUMO and...

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Bibliografske podrobnosti
izdano v:Cell Res
Main Authors: Yu, Fang, Shi, Guang, Cheng, Shimeng, Chen, Jiwei, Wu, Shwu-Yuan, Wang, Zhiqiang, Xia, Nansong, Zhai, Yunhao, Wang, Zhenxing, Peng, Yu, Wang, Dong, Du, James X., Liao, Lujian, Duan, Sheng-Zhong, Shi, Tieliu, Cheng, Jinke, Chiang, Cheng-Ming, Li, Jiwen, Wong, Jiemin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993822/
https://ncbi.nlm.nih.gov/pubmed/29588524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0023-9
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