Whole Exome Sequencing of Patients from Multicase Families with Systemic Lupus Erythematosus Identifies Multiple Rare Variants

In an effort to identify rare alleles associated with SLE, we have performed whole exome sequencing of the most distantly related affected individuals from two large Icelandic multicase SLE families followed by Ta targeted genotyping of additional relatives. We identified multiple rare likely pathog...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Delgado-Vega, Angélica M., Martínez-Bueno, Manuel, Oparina, Nina Y., López Herráez, David, Kristjansdottir, Helga, Steinsson, Kristján, Kozyrev, Sergey V., Alarcón-Riquelme, Marta E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993790/
https://ncbi.nlm.nih.gov/pubmed/29884787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26274-y
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