Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120

We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021, which targets the Phe43 cavity of the HIV-1 envelope glycoprotein gp120, to improve antiviral potency and ADMET properties. In this report, we present a structure-based approach that helped us to generate...

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Publicado en:Eur J Med Chem
Main Authors: Curreli, Francesca, Belov, Dmitry S, Do Kwon, Young, Ramesh, Ranjith, Furimsky, Anna M, O’Loughlin, Kathleen, Byrge, Patricia C, Iyer, Lalitha V, Mirsalis, Jon C, Kurkin, Alexander V, Altieri, Andrea, Debnath, Asim K
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993640/
https://ncbi.nlm.nih.gov/pubmed/29860061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.04.062
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