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A computational framework for predicting obesity risk based on optimizing and integrating genetic risk score and gene expression profiles

Recent large-scale genome-wide association studies have identified tens of genetic loci robustly associated with Body Mass Index (BMI). Gene expression profiles were also found to be associated with BMI. However, accurate prediction of obesity risk utilizing genetic data remains challenging. In a co...

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Pubblicato in:PLoS One
Autori principali: Joseph, Paule V., Wang, Yupeng, Fourie, Nicolaas H., Henderson, Wendy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993110/
https://ncbi.nlm.nih.gov/pubmed/29795655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197843
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