Impact of LINE-1 hypomethylation on the clinicopathological and molecular features of colorectal cancer patients

Recent studies suggest that aberrant DNA methylation might occur early and commonly in colorectal tumorigenesis. In 111 normal subjects, the mean LINE-1 methylation level of peripheral blood was 81.0 ± 5.7%. Of 143 colorectal cancer (CRC) patients, the mean level of LINE-1 methylation was 60.5 ± 12....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Kuan, Tai-Chuan, Lin, Pei-Ching, Yang, Shung-Haur, Lin, Chun-Chi, Lan, Yuan-Tzu, Lin, Hung-Hsin, Liang, Wen-Yi, Chen, Wei-Shone, Lin, Jen-Kou, Jiang, Jeng-Kai, Chang, Shih-Ching
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993106/
https://ncbi.nlm.nih.gov/pubmed/29795620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197681
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