Impact of LINE-1 hypomethylation on the clinicopathological and molecular features of colorectal cancer patients

Recent studies suggest that aberrant DNA methylation might occur early and commonly in colorectal tumorigenesis. In 111 normal subjects, the mean LINE-1 methylation level of peripheral blood was 81.0 ± 5.7%. Of 143 colorectal cancer (CRC) patients, the mean level of LINE-1 methylation was 60.5 ± 12....

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Kuan, Tai-Chuan, Lin, Pei-Ching, Yang, Shung-Haur, Lin, Chun-Chi, Lan, Yuan-Tzu, Lin, Hung-Hsin, Liang, Wen-Yi, Chen, Wei-Shone, Lin, Jen-Kou, Jiang, Jeng-Kai, Chang, Shih-Ching
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993106/
https://ncbi.nlm.nih.gov/pubmed/29795620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197681
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