Functional Consequences of the Postnatal Switch From Neonatal to Mutant Adult Glycine Receptor α1 Subunits in the Shaky Mouse Model of Startle Disease

Mutations in GlyR α1 or β subunit genes in humans and rodents lead to severe startle disease characterized by rigidity, massive stiffness and excessive startle responses upon unexpected tactile or acoustic stimuli. The recently characterized startle disease mouse mutant shaky carries a missense muta...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Principais autores: Schaefer, Natascha, Zheng, Fang, van Brederode, Johannes, Berger, Alexandra, Leacock, Sophie, Hirata, Hiromi, Paige, Christopher J., Harvey, Robert J., Alzheimer, Christian, Villmann, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992992/
https://ncbi.nlm.nih.gov/pubmed/29910711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00167
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