Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)

The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we have determined the structural basis for COX-1 binding to two diarylisoxazoles: mofezolac, which is polar and ionizable, and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Cingolani, Gino, Panella, Andrea, Perrone, Maria Grazia, Vitale, Paola, Di Mauro, Giuseppe, Fortuna, Cosimo G., Armen, Roger S., Ferorelli, Savina, Smith, William L., Scilimati, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992922/
https://ncbi.nlm.nih.gov/pubmed/28710965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.06.045
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