Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

BACKGROUND: Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities of...

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Vydáno v:Cancer Cell Int
Hlavní autoři: Uhl, Katie L., Schultz, Chad R., Geerts, Dirk, Bachmann, André S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Primary Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992763/
https://ncbi.nlm.nih.gov/pubmed/29977157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0574-3
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