Long-term toxicity, pharmacokinetics and immune effects of a recombinant adenovirus vaccine expressing human papillomavirus 16 E6 and E7 proteins (HPV16 E6E7-Ad5 Vac) in primates

Objective: This study aimed to: evaluate long-term toxicity and pharmacokinetic parameters; to identify the target organ of toxicity of a recombinant adenovirus vaccine expressing human papillomavirus 16 E6 and E7 proteins (HPV16 E6E7-Ad5 Vac) in primates; and to determine the specific immune respon...

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Vydáno v:Am J Transl Res
Hlavní autoři: Wu, Jie, Chen, Gang, Zhuang, Fang-Cheng, Gao, Meng, Wu, Chuan-Dong, He, Zhan-Long, Jiang, Yun-Shui, Li, Jian-Bo, Bao, Jia-Yuan, Mao, Zi-An
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992553/
https://ncbi.nlm.nih.gov/pubmed/29887967
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