Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons

Midbrain dopamine (DA) neurons are considered a critical substrate for the reinforcing and sensitizing effects of nicotine and tobacco dependence. While the role of the α4 and β2 subunit containing nicotinic acetylcholine receptors (α4β2(∗)nAChRs) in mediating nicotine effects on DA release and DA n...

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Publicat a:Front Pharmacol
Autors principals: Collo, Ginetta, Cavalleri, Laura, Zoli, Michele, Maskos, Uwe, Ratti, Emiliangelo, Merlo Pich, Emilio
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992464/
https://ncbi.nlm.nih.gov/pubmed/29910731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00572
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