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Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins

DNA is typically found as a double helix, however it must be separated into single strands during all phases of DNA metabolism; including transcription, replication, recombination and repair. Although recent breakthroughs have enabled the design of modular RNA- and double-stranded DNA-binding protei...

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Vydáno v:Nat Commun
Hlavní autoři: Spåhr, Henrik, Chia, Tiongsun, Lingford, James P., Siira, Stefan J., Cohen, Scott B., Filipovska, Aleksandra, Rackham, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992170/
https://ncbi.nlm.nih.gov/pubmed/29880855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04388-1
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