Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning

Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures. As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures. We have created a pipeline that combines high-throughput screening in...

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Publicat a:PLoS One
Autors principals: Sips, Patrick Y., Shi, Xu, Musso, Gabriel, Nath, Anjali K., Zhao, Yanbin, Nielson, Jason, Morningstar, Jordan, Kelly, Amy E., Mikell, Brittney, Buys, Eva, Bebarta, Vikhyat, Rutter, Jared, Davisson, V. Jo, Mahon, Sari, Brenner, Matthew, Boss, Gerry R., Peterson, Randall T., Gerszten, Robert E., MacRae, Calum A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991913/
https://ncbi.nlm.nih.gov/pubmed/29879736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193889
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