Nuclear m(6)A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

The N(6)-methyladenosine (m(6)A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m(6)A sites are found in the last exon and 3’ UTRs. Here we show that the nuclear m(6)A reader YTHDC1 is essential for embryo viability and germline development in mouse. Spec...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Kasowitz, Seth D., Ma, Jun, Anderson, Stephen J., Leu, N. Adrian, Xu, Yang, Gregory, Brian D., Schultz, Richard M., Wang, P. Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991768/
https://ncbi.nlm.nih.gov/pubmed/29799838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007412
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