Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma

Clear cell sarcoma (CCS) is an aggressive type of soft tissue tumor that is associated with high rates of metastasis. In the present study, we found that CPI-613, which targets tumorous mitochondrial energy metabolism, induced autophagosome formation followed by lysosome fusion in HS-MM CCS cells in...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Egawa, Yuki, Saigo, Chiemi, Kito, Yusuke, Moriki, Toshiaki, Takeuchi, Tamotsu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991736/
https://ncbi.nlm.nih.gov/pubmed/29879220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198940
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