Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation

Gfi1 is a key molecule in hematopoietic lineage development and mutations in GFI1 cause severe congenital neutropenia (SCN). Neutropenia is associated with low bone mass, but the underlying mechanisms are poorly characterized. Using Gfi1 knock-out mice (Gfi1-ko/ko) as SCN model, we studied the relat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Geissler, Sven, Textor, Martin, Stumpp, Sabine, Seitz, Sebastian, Lekaj, Anja, Brunk, Sabrina, Klaassen, Sabine, Schinke, Thorsten, Klein, Christoph, Mundlos, Stefan, Kornak, Uwe, Kühnisch, Jirko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991660/
https://ncbi.nlm.nih.gov/pubmed/29879182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198510
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