Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

BACKGROUND: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), which are variably expressed in the brain, has been demonstrated to reduce sei...

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Bibliographic Details
Published in:BMC Neurol
Main Authors: Erdogan, Mumin Alper, Yusuf, Dimas, Christy, Joanna, Solmaz, Volkan, Erdogan, Arife, Taskiran, Emin, Erbas, Oytun
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991447/
https://ncbi.nlm.nih.gov/pubmed/29879920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-018-1086-4
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