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Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth

Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. Chondroitin sulfate proteoglycans (CSPGs) are the major axon inhibitory matrix component that is increased within the lesion sc...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tran, Amanda Phuong, Sundar, Sapna, Yu, Meigen, Lang, Bradley T., Silver, Jerry
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990985/
https://ncbi.nlm.nih.gov/pubmed/29760175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3214-17.2018
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