Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth

Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. Chondroitin sulfate proteoglycans (CSPGs) are the major axon inhibitory matrix component that is increased within the lesion sc...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Tran, Amanda Phuong, Sundar, Sapna, Yu, Meigen, Lang, Bradley T., Silver, Jerry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990985/
https://ncbi.nlm.nih.gov/pubmed/29760175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3214-17.2018
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