Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress

Nakajo-Nishimura syndrome (NNS) is an immunoproteasome-associated autoinflammatory disorder caused by a mutation of the PSMB8 gene. Although dysfunction of the immunoproteasome causes various cellular stresses attributed to the overproduction of inflammatory cytokines and chemokines in NNS, the unde...

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Udgivet i:Stem Cell Reports
Main Authors: Honda-Ozaki, Fumiko, Terashima, Madoka, Niwa, Akira, Saiki, Norikazu, Kawasaki, Yuri, Ito, Haruna, Hotta, Akitsu, Nagahashi, Ayako, Igura, Koichi, Asaka, Isao, Li, Hongmei Lisa, Yanagimachi, Masakatsu, Furukawa, Fukumi, Kanazawa, Nobuo, Nakahata, Tatsutoshi, Saito, Megumu K.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989695/
https://ncbi.nlm.nih.gov/pubmed/29731430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.004
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